Name: AICAR (Acadesine)
CAS No.: 2627-69-2
Other Name: Acadesine; GP 1-110; Arasine; ACADESINE; 5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide; Z-RIBOSIDE; 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside; 5-amino-4-imidazole carboxamide ribonucleoside; AIC-Riboside; Acadesine,AICA; AICA-RIBOSIDE; AMPK
Melting point: 214-215ºC
Boiling Point: 726.3ºC at 760 mmHg
Flash point: 393.1ºC
Density: 2.06 g/cm3
Storage temp.: -20ºC
Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis.
Acadesine (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in.
(1) Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.
(2) Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
(3) Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.
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