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Raw Sarm Powder GW0742 PPARβ Agonist SARM Powder Anti-Cancer CAS 317318-84-6

Raw Sarm Powder GW0742 PPARβ Agonist SARM Powder Anti-Cancer CAS 317318-84-6

    • Raw Sarm Powder GW0742 PPARβ Agonist SARM Powder Anti-Cancer CAS 317318-84-6
    • Raw Sarm Powder GW0742 PPARβ Agonist SARM Powder Anti-Cancer CAS 317318-84-6
  • Raw Sarm Powder GW0742 PPARβ Agonist SARM Powder Anti-Cancer CAS 317318-84-6

    Product Details:

    Place of Origin: SHANGHAI
    Brand Name: YIJING
    Certification: ISO, GMP
    Model Number: 317318-84-6

    Payment & Shipping Terms:

    Minimum Order Quantity: 10grams
    Price: USD1-2/gram
    Packaging Details: customized
    Delivery Time: 3 workdays
    Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
    Supply Ability: 50KGS/month
    Detailed Product Description
    Purity: 99% MF.: C21H17F4NO3S2
    MW.: 471.49 Flash Point: 311.514ºC
    Boiling Point: 591.476ºC At 760 MmHg

    Basic Information:
    Name: GW0742
    CAS No.: 317318-84-6
    Other Name: GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID;4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]AceticAcid;4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid;Acetic acid, 2-[4-[[[2-[3-fluoro-4-(trifluoroMethyl)phenyl]-4-Methyl-5-thiazolyl]Methyl]thio]-2-Methylphenoxy]-;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW 0742X
    MF.: C21H17F4NO3S2
    MW.: 471.49
     
    Chemical Property:
    Appearance: Solid
    Boiling Point: 591.476ºC at 760 mmHg
    Flash point: 311.514ºC
    Density: 1.462g/cm3
    Storage temp.: -20ºC
     
    Description:
    A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.
    GW0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes. GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay. The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes. GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.
    GW0742 (GW610742) is a potent and highly selective PPARδ agonist. EC50 values are 1nM, 1.1μM and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. IC50 value: 1nM, 1.1μM and 2 μM (EC50, for PPARδ, -α, and -γ) Target: PPAR in vivo: GW0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of: 1) cytokine production; 2) leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; 3) IkBα degradation and NF-kB nuclear translocation; 4) ERK phosphorylation; 5) stress oxidative by NO formation due to iNOS expression; 6) nitrotyrosine and PAR localization; 7) the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO--instillation in mice.
     
    Raw Sarm Powder GW0742 PPARβ Agonist SARM Powder Anti-Cancer CAS 317318-84-6
     

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